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KMID : 1237720110440040331
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Anatomy & Cell Biology
2011 Volume.44 No. 4 p.331 ~ p.336
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Increase in concentration of soluble HLA-G in high-quality embryos after intracytoplasmic sperm injection
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Heidari Mohammad Hassan
Novin Marefat Ghaff ari
Ahmadi Farzaneh
Khorshid Mehran
Najafi Tohid
Molouki Aidin
Salehpour Saghar
Bandehpour Mojgan
Heidari Matineh
Sato Eimi
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Abstract
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Non-invasive methods are normally preferred to conventional invasive methods when selecting suitable embryos to improve pregnancy rates after assisted reproduction techniques. One of the most recognized non-invasive methods is to examine the supernatants of embryo culture media. Soluble human leukocyte antigen, class I, G (sHLA-G) antigen is a non-classical class I molecule that has been widely considered as a marker of pregnancy failure or implantation success. In the current study of some Iranian patients, we examined the concentration of sHLA-G at different time points after intracytoplasmic sperm injection and compared the rates to the morphology and quality of the selected embryos. We showed that the concentration of sHLA-G increases over time in high-quality embryos. We conclude that there is a positive relationship between morphology, quality, and sHLA-G concentration. We suggest that this relationship can be used to increase the chance of a successful pregnancy.
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KEYWORD
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HLA antigen, Assisted reproductive techniques, Intracytoplasmic sperm injections
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